John E. Wagner, M.D., Co-Director

John E. Wagner, M.D., is a Professor of Pediatrics and Division Director of the Hematology-Oncology and Blood and Marrow Transplantation Program. He is Scientific Director of Clinical Research of the Stem Cell Institute at the University of Minnesota Medical School. In addition, Dr. Wagner is the Scientific Director of Molecular and Cellular Therapeutics and the Clinical Trials Office of the NCI designated Cancer Center at the University of Minnesota. He is an experienced clinical investigator in the field of marrow transplantation and has 16 years of experience leading phase I/II studies specifically in the area of marrow graft engineering using physical and immunological methods and umbilical cord blood hematopoietic stem cells.

Educational Background

• B.A., Biological Science & Psychology, University of Delaware, Newark, Delaware, 1973 - 1977
• M.D., Medicine, Jefferson Medical College, Philadelphia, Pennsylvania, 1977 - 1981
• Fellow, St. Christopher's Society, Philadelphia, Pennsylvania, 1978
• Intern, Pediatrics, Duke University Medical Center, Durham, North Carolina, 1981 - 1982
• Resident, Pediatrics, Duke University Medical Center, 1982 - 1984
• Postdoctoral Fellow, Oncology, The Johns Hopkins University School of Medicine, Maryland, 1984 - 1987
• Postdoctoral Fellow, Pediatrics, The Johns Hopkins University School of Medicine, 1984 - 1987

Professional Background

• Instructor, The Johns Hopkins University School of Medicine, Oncology, 1987 - 1988
• Instructor, The Johns Hopkins University School of Medicine, Pediatrics, 1988
• Assistant Professor, The Johns Hopkins University School of Medicine, Oncology & Pediatrics, 1988 - 1991
• Assistant Professor, University of Minnesota Medical School, Pediatrics, 1991 - 1993
• Attending Physician, University of Minnesota Medical School, Pediatric Bone Marrow Transplant Unit, 1991 - present
• Associate Professor, University of Minnesota Medical School, Pediatrics, 1993 - 1999
• Member, University of Minnesota Cancer Center, 1994 - present
• Associate Director, University of Minnesota Medical School, Pediatric Bone Marrow Transplantation, 1995 - present
• Director, Fairview-University Medical Center , Bone Marrow Transplant New Program, 1997 - present
• Professor of Pediatrics, University of Minnesota Medical School, Pediatrics, 1999 - present
• Associate Member, University of Minnesota, Division of Epidemiology, School of Public Health, 2000 - present
• Scientific Director of Clinical Research, University of Minnesota , Blood & Marrow Transplantation and Stem Cell Institute, 2000 ¿ present
• Director, Division of Pediatric Hematology/Oncology and Blood & Marrow Transplantation, 2005 - present

Professional Honors

• National Honor Society, Professional Honors, 1973
• Cum Laude, University of Delaware, 1977 - present
• Outstanding College Graduate, Jefferson Medical College, 1981 - present
• Dean Marie Baines Award for Excellence in Pediatrics, Jefferson Medical College, 1981 - present
• Magna Cum Laude, Jefferson Medical College, 1981 - present
• Recipient, American Cancer Society Post-Doctoral Training Award , American Cancer Society, 1984 - present
• Higgins Scholar in Oncology Research, Hodson Trust, 1989 - 1991
• Presidential Symposium, International Society of Experimental Hematology-Parm, 1991 - present
• Jundt Research Award, 1993 - present
• Plenary Symposium, American Society of Hematology, 1993 - present
• Presidential Symposium, European Bone Marrow Transplantation-Harrogate, Un, 1994 - present
• Year in Hematology Session, The Clinical Research Meeting-Baltimore, Maryland, 1994 - present
• Plenary Symposium, International Society of Experimental Hematology-D, 1995 - present
• Plenary Symposium, International Society of Experimental Hematology-N, 1996 - present
• Plenary Symposium, American Society of Histocompatibility and Immunol, 1997 - present
• Election, American Society of Clinical Investigation, 2000 ¿ present
• Election, Association of American Physicians, 2006 - present

Professional Memberships

• Alpha Omega Alpha, 1980 - present
• American Medical Association, 1981 - 1983
• Fellow American Academy of Pediatrics, 1982 - 1984
• American Society of Pediatric Hematology/Oncology, 1988 - 1995
• American Society of Hematology, 1989 - present
• International Society of Experimental Hematology, 1989 - present
• Northwestern Pediatric Society, 1992 - 1993
• International Society of Hematotherapy and Graft Engineering, 1992 - 2001
• American Society of Blood and Marrow Transplantation, 1993 - present
• American Society of Clinical Investigation, 2000 ¿ present
• Association of American Physicians, 2006 - present

Community and University Service

• Committee on Clinical Investigation in Human Subjects, 1993-current
• University of Minnesota Co-Team Leader, Stem Cell Biology Program, Medical School Research Priority Programs, 2001
• Dean's Research Advisory Panel , 2002
• Stem Cell Institute Ethics Advisory Board (ex-officio), 2001-current
• Medical School Clinical Research Committee, 2002  (David Cornfield, Chair)
• Translational Research Advisory Group,  2002-current  (Mark Paller, Chair)

Patents

Patent number: 93063Citation: U.S. Patent Application filed November 16, 1992. University Docket No. 93063 [Pluripotential Quiescent Stem Cell Population]

Publications  (Selected from 128 Publications)

Porter SB, Liu B, Rogosheske J, Levine BL, June CH, Kohl VK, Wagner JE , Miller JS, Blazar BR.  Suppressor Function of Umbilical Cord Blood (UCB) Derived CD4 + CD25 + T-Regulatory (Treg) Cells Exposed to Graft-Versus-Host Disease (GVHD) Drugs.  Transplantation.  In Press (2006).

Eapen M, Rubinstein P, Zhang MJ, Camitta B, Stevens C, Cairo MS, Davies SM, Doyle JJ, Kurtzberg J, Pulsipher MA, Ortega JJ, Scaradavou A, Horowitz MM, Wagner JE .  Comparable Long-Term Survival After Unrelated and HLA-Matched Sibling Hematopoietic Stem Cell Transplants for Acute Leukemia in Children Less Then 18 Months. J. Clin Oncology. 24 :145-151 (2006).

Wagner JE , Thompson JS, Carter SL, Kernan NA.  Effect of Graft-versus-Host Disease Prophylaxis on 3-Year Disease Free Survival in Recipients of Unrelated Donor Bone Marrow Transplantation: Results of a Multi-Center, Randomized Phase II-III Trial.  Lancet. 366 :733-41 (2005).

Barker J, Hough RE, van Burik J, DeFor T, MacMillan ML, O'Brien MR, Wagner JE .  Serious Infections After Unrelated Donor Transplantation in 136 Children: Impact of Stem Cell Source.  Biol  Blood Marrow Tranplant. 11 :362-70 (2005).

Miller JS, Soignier Y, Panoskaltsis-Mortari A, McNearney S, Yun G, Fautsch SK, McKenna D, Le C, Defor TE, Burns LJ, Orchard PJ, Blazar BR, Wagner JE , Slungaard A, Weisdorf DJ, Okazaki IJ, McGlave PB.  Successful Adoptive Transfer and InVivo Expansion of Human Haploidentical NK Cells in Cancer Patients.  Blood. 105 :3051-7 (2005).

Wagner JE , Kahn JP, Wolf SM, Lipton FM.  Preimplantation Testing to Produce an HLA Matched Donor Infant.  JAMA 292 :803-804 (2004).

Eapen M, Horowitz MM, Klein JP, Champlin RE, Loberiza FR, Ringden O, Wagner JE .  Higher Mortality after Allogeneic Peripheral-Blood Transplantation Compared With Bone Marrow in Children and Adolescents: The Histocompatibility and Alternative Stem Cell Source Working Committee of the International Bone Marrow Transplant Registry.  J Clin Oncol. 22 :4872-80 (2004).

Barker JN, Weisdorf DJ, DeFor TE, Blazar, McGlave PB, Miller JS, Verfaillie CM, Wagner JE .   Transplantation of Two-Partially HLA-Matched Umbilical Cord Blood Units To Enhance Engraftment in Adult with Hematologic Malignancy.   Blood 105 :1343-7 (2004).

Wagner JE , Verfaillie CM.  Ex vivo Expansion of Umbilical Cord Blood Hemopoietic Stem and Progenitor Cells.  Exp Hematol 32 :412-413 (2004).

Laughlin MJ, M Eapen, Rubinstein P, Wagner JE , Zhang MJ, Champlin RE, Stevens CE, Barker JN, Gale RP, Lazarus HM, Marks DI, van Rood JJ, Scaravadou A, Horowtiz MM.  Outcomes After Transplantation of Cord Blood or Bone Marrow from Unrelated Donors in Adults with Leukemia.  New Engl J Med.  22 :2265-75 (2004).

Wagner JE , Tolar J, Levran O, Scholl T, Deffenbaugh A, Satagopan J, Ben-Porat L, Mah K, Batish S, Kutler D, MacMillan M, Hanenberg H, Auerbach A. Germline Mutation in BRCA2: Shared Genetic Susceptibility to Breast Cancer, Early Onset Leukemia and Fanconi Anemia. Blood. 103:3226-9 (2004).

Grewal SS, MacMillan ML, Kahn JP, Ramsay NKC, Wagner JE . Successful Hematopoietic Stem Cell Transplantation for Fanconi Anemia from an Unaffected HLA Genotypically- Identical Sibling Selected Using Preimplantation Genetic Diagnosis. Blood. 103:1147-1151 (2004).

Barker JN, Wagner JE . Umbilical Cord Blood Transplantation for the Treatment of Cancer. Nature Reviews Cancer 3:526-32 (2003).

Wolf SJ, Kahn JP, Wagner, JE . Using Preimplantation Genetic Diagnosis to Create Stem Cell Donor: Issues, Guidelines & Limits. Journal of Law, Medicine and Ethics. 31:327-339 (2003).

Barker JN, Weisdorf DJ, DeFor TE, Blazar BR, Miller JS, Wagner JE . Rapid and Complete Donor Chimerism in Adult Recipients of Unrelated Donor Umbilical Cord Blood Transplantation after Reduced Intensity Conditioning. Blood. 102:1915-9 (2003).

Wagner JE , Barker JN, DeFor T, Baker KS, Blazar BR, Eide C, Goldman A, Kersey J, Krivit W, MacMillan M, Orchard P, Peters C, Weisdorf DJ, Ramsay NKC, Davies SM. Transplantation of Unrelated Donor Umbilical Cord Blood in 102 Patients with Malignant and Non-Malignant Diseases: Influence of CD34 Cell Dose and HLA Disparity on Treatment-Related Mortality and Survival. Blood advanced on line publication. Blood. 100:1611-8 (2002).

Grewal SS, Barker JN, Davies SM, and Wagner JE . Unrelated donor hematopoietic cell transplantation: marrow or umbilical cord blood? Blood. 101:4233-44 (2003).

Barker JN, Weisdorf DJ, Wagner JE . Creation of a double chimera after the transplantation of umbilical-cord blood from two partially matched unrelated donors. N Engl J Med. 344:1870-1871 (2001).

Gregory JJ, Wagner JE , Verlander PC, Levran O, Batish SD, Eide CR, Steffenhagen A, Hirsch B, Auerbach AD. Somatic Mosaicism in Fanconi Anemia: Evidence of Genotypic Reversion in Lymphohematopoietic Stem Cells. Proc Nat Acad Sci. 98:2532-2537 (2001).

Barker JN, Davies SM, DeFor T, Ramsay NKC, Weisdorf DJ, Wagner JE . Survival After Transplantation of Unrelated Donor Umbilical Cord Blood is Comparable to that of Human Leukocyte Antigen-Matched Unrelated Donor Bone Marrow: Results of a Matched-Pair Analysis. Blood. 97:2957-2961 (2001).