Copyright 2008 University of Minnesota Board of Regents.
The University of Minnesota is an equal opportunity educator and employer.
Patrick J. Manning Research Grant Program
The University of Minnesota is among the top 10 public research universities nationwide. Animal research is fundamental to this success having advanced numerous medical treatments, techniques, and technologies to benefit human and animal health. The contribution of our animals is immense and it is an enormous privilege to work with them.
The guiding principles underpinning the humane use of sentient animals in scientific research are called the Three Rs, representing replacement, reduction, and refinement. The University requires researchers who are planning to use animals in their research to first show why there is no alternative and what will be done to minimize both numbers and potential distress.
The Patrick J. Manning endowment has provided a source of funding to award a University employee or graduate student for research proposals that will advance knowledge and application of the 3Rs and laboratory animal welfare. All proposals should contribute to improving the welfare of animals that support the research mission of the University of Minnesota.
Proposals may complement existing research or may be made in their own right. Proposals relevant to any area of medical, biological or veterinary research or testing can be considered and applications that integrate a range of disciplines are welcomed.
Upon successful completion, individuals may be invited to present their findings at a symposium or research poster session. It is hoped (but not required) that successful applicants will be able to submit a manuscript of their project and its outcome to an appropriate journal.
Refinement: improvements to husbandry and procedures that minimize actual or potential pain, suffering, distress or lasting harm and/or improve animal welfare in situations where the use of animals is unavoidable. There is clear evidence that refinement not only benefits animals, but also improves the quality of research findings. Refinement of a research technique may result in the use of less invasive procedures or less stressful methodologies. Proposals may, for example, examine:
o how adverse physiological and behavioral stress responses to common husbandry (e.g., capture) and traditional treatment procedures (e.g., drug administration or blood collection) can be reduced or eliminated (e.g., training animals to co-operate with certain procedures so the animals are less stressed);
Reduction: methods which minimize animal use and enable researchers to obtain comparable levels of information from fewer animals or to obtain more information from the same number of animals, thereby reducing future use of animals. Proposals may, for example, examine:
o improved experimental design, which requires a smaller number of animals (e.g. biopsy versus euthanasia and tissue harvest)
o statistical analysis tools
o novel techniques, such as imaging, which require smaller numbers of animals
o Programs for tissue or data sharing
Replacement: methods that avoid or replace the use of animals in an area where animals would otherwise have been used. This includes both absolute and relative replacements. Proposals may, for example, examine the use of:
o computer modeling, in vitro methodologies
o established animal cell lines and animal cells, tissues and organs where the animal was sacrificed by a humane technique before collection of the material
o abattoir material
Eligibility: University of Minnesota civil service, bargaining unit, and student employees are eligible to submit applications. Faculty and P&A staff are not eligible.
Submission guidelines: the proposal itself should be in the form of a two-page research plan that clearly states the objectives of the study and the anticipated outcomes. It should provide sufficient detail so that reviewers can understand what is being proposed, how it will be achieved, and how the data will be evaluated.
· background and relevance of the project - specifically comment on the relevance of the study to the advancement of scientific knowledge in the fields of laboratory animal science and medicine and/or to the benefit the health and well being of laboratory animals
· objectives or specific aims of the research
· outline of the experimental design
· timeline for the study
· simple budget (not to exceed $500) include supplies needed, other expenses
Deadlines and Review: The deadline for submission of these applications will be set each year and the PJM Research Grant Review Committee will review and make the final decisions on those applications to be funded. Successful applicants will be notified in writing and by email. Before work begins an IACUC Animal Usage Form must be submitted and approved (or a currently approved protocol can be amended by the Principal Investigator).
For more information and to submit applications, contact: Research Animal Resources, Attn: Manning Research Grant Program, MMC 351, 612-624-9100
The Patrick J. Manning Research Award honors two University staff or students.
Awards will be presented at the annual appreciation luncheon and will consist of a plaque and a $500 honorarium. Nominations should take the form of a single letter by the candidate and signed by a supervisor or a letter from the candidate's supervisor or colleague. The award is intended for University staff or students (not Faculty) who work with research animals. The short letter should summarize the candidate's contributions. Nominations are due early each spring.
The Patrick J. Manning award recognizes special effort in the care and use of research animals and contributions to biomedical research. Examples of the kinds of accomplishments the award seeks to honor include:
The award is a memorial to Dr. Patrick J. Manning, D.V.M, who directed the University's Research Animal Resources from 1974 until his death in 1994. Dr. Manning was also a professor in the Department of Laboratory Medicine and Pathology.
Pat was always an active member of the laboratory animal medicine community. He served on the boards of the American College of Laboratory Animal Medicine (ACLAM) and the American Association for Laboratory Animal Science (AALAS) as well as president of ACLAM. AALAS honored Pat with the Charles A. Griffin award for outstanding contribution to laboratory animal science in 1985. Pat was an ardent supporter of the American Association for Accreditation of Laboratory Animal Care (AAALAC) and served as chair of the AAALAC from 1981 – 1983. Pat edited two ACLAM texts during his career, most recently The Biology of the Laboratory Rabbit published in 1994. Pat’s true love was research and he served on numerous NIH study sections, as a consultant to the Division of Research Resources, on Institute of Laboratory Animal Resources Advisory councils, and was on the Scientific Advisory Board for the National Center for Toxicological Research. He published over 50 articles in his career.
At the University of Minnesota, Pat organized, managed, and directed Research Animal Resources (RAR), the veterinary service, care and teaching department which provides direct support to researchers using laboratory animals in the Health Sciences. He improved the animal care and use program to a point where the Health Sciences achieved AAALAC accreditation in 1984 and has maintained that accreditation since. In his role as Director of RAR, Pat often had to speak out publicly to defend the University’s use of animals in research and education. Pat always felt strong about the need for laboratory animal veterinarians to have a strong research background and trained several veterinary residents in that tradition.
Dr. Patrick J. Manning cast a big shadow and is missed.
The information contained in this site is intended as a reference for University of Minnesota investigators, and animal husbandry and veterinary staff. Drug information and dosages are derived from a variety of sources and do not necessarily guarantee safety or efficacy. Information obtained through this site should not be relied upon as professional veterinary advice. Any medications administered or procedures performed on animals should only be performed by or under order of a qualified, licensed veterinarian.