Copyright 2005, University of Minnesota Board of Regents.
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GUIDELINES FOR MANDATORY TESTING OF CELL LINES AND OTHER BIOLOGICS PRIOR TO ADMINISTRATION TO RODENTS
- Rodent blood-products, cell lines and tissues, including rodent tumor cells/tissues must be tested for rodent infectious agents prior to being administered to rodents housed in RAR-managed facilities (ATCC does not test for rodent agents).
- Non-rodent blood-products, cell lines/tissues which have been passed through rodents or have been in contact with rodent cells/tissues or rodent blood-products must also be tested.
There are three exceptions:
- Cell lines/ tissues or blood-products that were harvested from rodents housed in RAR-managed rodent facilities of the same or higher biologic status (MPV-negative SPF > MPV-positive SPF > Conventional > BSL-2) as housing of the new recipients do not have to be tested unless they have subsequently been passed through rodents of a lower biologic status or exposed to rodent blood-products of a lower biologic status.
- Cell lines or tissues that have previously been administered to rodents housed in RAR-managed rodent facilities of the same or higher biologic status (MPV-negative SPF > MPV-positive SPF > Conventional > BSL-2) as housing of the new recipients do not have to be tested unless they have subsequently been passed through rodents of a lower biologic status or exposed to rodent blood-products of a lower biologic status.
- Cell lines or tissues administered to rodents housed in ABSL-2 housing.
The information contained in this site is intended as
a reference for University of Minnesota investigators, and animal husbandry
and veterinary staff. Drug information and dosages are derived from a variety
of sources and do not necessarily guarantee safety or efficacy. Information
obtained through this site should not be relied upon as professional veterinary
advice. Any medications administered or procedures performed on animals
should only be performed by or under order of a qualified, licensed veterinarian. |
