| AHC Seed Grant Recipients |
| Title |
Principal Investigator(s) |
College |
Request |
| Seed Grant Summary 2008 |
|
|
|
| Structural studies of the NL63 coronavirus spike protein by cryo-electrom microscopy |
Fang Li, Ph.d. |
Medical School |
$25,000 |
| Novel role for Rtf1 in dedifferentiation and acquisition of pluripotency |
Nobuaki Kikyo, MD, Ph.D. |
Medical School |
$25,000 |
| A novel role of The Cohesin Ring in Centrosome Dynamics |
Duncan J. Clarke, Ph.D. |
Medical School |
$25,000 |
| Identification of genes that regulate in the selective packaging and transport of C. elegans LRP-1 |
Sean D. Conner, Ph.D. |
Medical School |
$25,000 |
| Role of Two-component Signal SaeRS Regulator in Biofilm Formation of Staphylococcus aureus |
Yinduo Ji, Ph.D. |
College of Veterinary Medicine |
$25,000 |
| Translational Control of Regulatory T Cell Induction |
Alexander Khoruts, M.D. |
Medical School |
$25,000 |
| Information-seeking and decision-making preferences among orthodontic patients: an elective health care model |
James R. Miller, DDS, MS |
School of Dentistry |
$25,000 |
| Whole-body MRI Bone Marrow Staging of Canine Lymphoma: a potential animal model |
Daniel A. Feeney, DVM, MS |
College of Veterinary Medicine |
$25,000 |
|
Reproduction and immune function in Pteropus bats: Improving bio-monitoring capacity in a major wildlife reservoir for emerging infectious disease
|
Katharine M. Pelican, DVM, Ph.D. |
College of Veterinary Medicine |
$25,000 |
| Integration of Neuroimaging and Biomechanics of Low Back Pain |
David J. Nuckley, Ph.D. |
Medical School |
$25,000 |
| Effects of Opioids on the Developing Rat Brain |
Raghavendra Rao, MD |
Medical School |
$25,000 |
| Neural Circuit Plasticity in Models of Depressive Illness |
Mark Thomas, Ph.D. |
Medical School |
$25,000 |
| High Throughput Screening the IGF - IR/GIPC Interaction: A New Strategy for Chemotherapy |
David M. Ferguson, Ph.D. |
College of Pharmacy |
$25,000 |
| Cellular Therapy for Epidermolysis Bullosa |
Jakub Tolar, MD, Ph.D. |
Medical School |
$24,596 |
| Novel live safe vaccine strategy against cytomegalovirus in the mouse model |
Alistair Mcgregor, Ph.D. |
Medical School |
$25,000 |
| Seed Grant Summary 2007 |
|
|
|
| Stress-Induced Binge Eating: A Prelude of Obesity |
|
|
|
$25,000 |
| Mechanisms of Drug Addiction: the Role of a New Gene, R7BP |
|
|
|
$25,000 |
| Stimulation of alveolar fluid clearance by carbonic anhydrase inhibition |
|
|
|
$25,000 |
| Hypocretin Mechanisms in Nicotine Reinforcement |
|
| William A. Corrigall, PhD |
|
|
$24,760 |
| Curing Prion Disease with Recombinant Prior Proteins |
|
|
| College of Veterinary Medicine |
|
$25,000 |
| Screening, Design and Optimization of Novel Small-Molecule, Druglike Anthrax Toxin Lethal Factor (LF) Inhibitors |
|
|
|
$25,000 |
| ACE-MSCs as Therapeutic Cytoreagents |
|
|
|
$25,000 |
| Testing of an Active Noise Cancellation System for Infant Incubators |
|
| Janet Lyn Fitzakerley, PhD |
|
|
$21,861 |
| Diabetic phenotype of adenosine receptor 2A deficient mice |
|
|
|
$25,000 |
| The Mechanism of Stromal Cell Induced Commitment of Hematopoietic Progenitor Cells to the NK Cell Lineage |
|
|
|
$25,000 |
| Application of aptamer coated magnetic nanosensors to pathogen detection in complex matrices |
|
| Srinand Sreevatsan, MVSc, MPH, PhD |
|
| College of Veterinary Medicine |
|
$25,000 |
| A Novel Mechanical-Optical Probe for evaluating Cartilage and Osteoarthritis |
|
|
|
$25,000 |
| Novel Γ-Lactone/Lactam-Β-Lactone Hybrid Molecules as Non-Peptidyl Proteasome Inhibitors |
|
| Venkatram R. Mereddy, PhD |
|
|
$25,000 |
| Neovasculogensis after chronic hypoxia |
|
|
|
$21,020 |
| |
|
|
|
| Seed Grant Summary 2006 |
|
|
|
| The Role of delta-EF1 in Skeletal Patterning |
Michel M. Sanders |
Medical School |
$25,000 |
| SCF Ubiquitin Ligases and DNA Replication |
Deanna Koepp |
Medical School |
$25,000 |
| Identification and tracking of novel antibiotic resistance genes in bacteria isolated from wastewater treatment plants |
Jeffrey A. Gralnick |
Medical School |
$25,000 |
| The Control of Adipose Biology by the Renin-Angiotensin System |
Stephen A. Katz |
Medical School |
$24,982 |
| Development of an in vivo assay system to study gene function in the chick retina |
Naoko Koyano-Nakagawa |
Medical School |
$25,000 |
| Gene Therapy for Parkinson's |
John Ohlfest |
Medical School |
$24,933 |
| Role of a Chromatin-Modifying Enzyme in Prostate Cancer |
Jeffrey A. Simon |
Medical School |
$25,000 |
| Energy Metabolism of Pancreatic Islets: Effects of Oxygenation Status and Antioxidants |
Gulin Oz |
Medical School |
$25,000 |
| Biosphosphate Associated Osteonecrosis of the Jaws: Utilization of a Novel Dual Energy Micro-CT Protocol to Study Changes in Vascular Characteristics and Bone Changes |
Rajaram Gopalakrishnan |
School of Dentistry |
$25,000 |
| Structural Basis of Sleeping Beauty - Mediation Transposition |
Irina Nesmelova |
Medical School |
$25,000 |
| Gold Nanoparticles for Delivery of Transposons to the Liver |
Stephen C. Ekker |
Medical School |
$25,000 |
| Latino Mental Health |
Nancy C. Raymond |
Medical School |
$24,926 |
| A feasibility study of a novel Ca marker to asses bone turnover for breast cancer patients treated with aromatase inhibitor and bisphosphonate drug |
Susanta Hui |
Medical School |
$24,888 |
| Biomechanics of Fetal Membrane Rupture |
Phillip Rauk |
Medical School |
$25,000 |
| Self-gelling Antimicrobial System for Infection Prevention in Root Canal |
Walter Bowles |
School of Dentistry |
$25,000 |
| |
|
|
|
| Seed Grant Summary 2005 |
|
|
|
| Comparison of X chromosome inactivation in multipotent adult progenitor cells and embryonic stem cells |
Nobuaki Kikyo, M.D., Ph.D. |
Medical School |
$25,000 |
| Kinetic Determinants of Ubiguitin Signaling |
Kylie Walters, Ph.D. |
Medical School |
$24,944 |
| Differentiation of Cochlear Progenitor Cells from Bone Marrow Stem Cells in Mice |
Jizhen Lin, M.D. |
Medical School |
$25,000 |
| Biosynthesis of cytotoxic mushroom sesquiterpenes as anticancer drugs |
Claudia Schmidt Dannert, Ph.D. |
Medical School |
$25,000 |
| Intranasal Application of Neuroprotective Agents in Rats with Anterior Ischemic Optic Neuropathy |
Linda McLoon, Ph.D. |
Medical School |
$25,000 |
| A Randomized, Double-Blinded, Placebo-Controlled Study of Intra-articular Botulinum Toxin A for Painful Prosthetic Hip Joint |
Jasvinder Singh, M.D., M.P.H. |
Medical School |
$25,000 |
| Effect of Altered Arginine Metabolism in Asthma |
Mark Rutherford, Ph.D. |
College of Veterinary Medicine |
$25,000 |
| Chemical Synthesis and Biophysical Analysis of Peptides for HIV Therapeutics |
Christine Karim, Ph.D. |
Medical School |
$25,000 |
| The role of CD4+CD3-accessory cells in regulation of T cell responses and autoimmunity |
Alexander Khoruts, M.D. |
Medical School |
$25,000 |
| Antibiotics from Unculturable Microorganisms |
Wayne Shier, Ph.D. |
College of Pharmacy |
$25,000 |
| Functional Genomics Analyses of Highly Pathogenic Avian Influenza |
Vivek Kapur, BVSc, PhD |
Medical School |
$25,000 |
| Algorithms for Identification of Acute Stroke Cases in Medicare Data |
Kamakshi Lakshminarayan, M.D., Ph.D. |
Medical School |
$22,770 |
| Identifying signaling pathway-specific kinase targets using a functional proteomics approach |
Ameeta Kelekar, Ph.D. |
Medical School |
$24,997 |
| |
|
|
|
| Seed Grant Summary 2004 |
|
|
|
| Regulation of Diabetes by Suppressor T Cells |
Michael A. Farrar |
Medical School |
$25,000 |
| NMDA Receptor Function and Circadian Time |
Paulo Kofuji |
Medical School |
$25,000 |
| Treatment of Plasmodium falciparum Parasitemia in Rural HIV-Infected Tanzanian Adults Initiating Highly Active Antiretroviral Therapy |
Alan Lifson |
Medical School |
$25,000 |
| Unexpected apoptotic effect of small peptide on human cancer |
Tucker Lebien |
Medical School |
$25,000 |
| Gene Expression Profiling of Lesion Subtypes in a Transgenic Mouse Model of Breast Tumorigenesis |
Teresa Rose-Hellekant |
Medical School-Duluth |
$25,000 |
| The Influence of electrical charge on filtration of an airborne biological agent |
Peter Raynor |
School of Public Health |
$24,996 |
| Use of Geographical Information Systems for Research into Endemic and Emerging Diseases of Swine (PRRS) |
Peter Davies |
College of Veterinary Medicine |
$25,000 |
| The Role of Endothelial Cell Tissue Factor during Vascular Remodeling |
David Basi |
School of Dentistry |
$25,000 |
| Role of Endosomal Adapter Proteins in Localization of BACE1 (B-site APP-Cleaving Enzyme) |
Patricia Scott |
Medical School-Duluth |
$24,543 |
| Reovirus subversion of the unfolded protein response |
Leslie Schiff |
Medical School |
$25,000 |
| Magnetic resonance probes of Duchenne Muscular Dystrophy |
David Thomas |
Medical School |
$25,000 |
| Evaluation of Activin Signaling Proteins in Head and Neck Cancer |
Patrick Gaffney |
Medical School |
$25,000 |
| |
|
|
|
| Seed Grant Summary 2003 |
|
| The Role of MUC2 in Min Tumorigenesis |
Robert Cormier |
Duluth SOM |
$25,000 |
| Sensitizing Neuroblastoma Cells to Immune-Based Therapies |
Michael Verneris |
Medical School |
$25,000 |
| Role of Tsg in Patterning and Development of the Mandible |
Rajaram Gopalakrishnan |
Dentistry |
$25,000 |
| Global Analysis of mRNA in Reovirus-Infected T Cells |
Paul Bohjanen |
Medical School |
$25,000 |
| Identification of Human smORFs |
Edward Perkins |
Duluth SOM |
$23,442 |
| Pharmacogenomic Identification of a Novel Gene Target, Sprouty 1 |
Jennifer Hall |
Medical School |
$25,000 |
| 3D Co-Culture of Oseoblasts and Endothelial Cells |
Mansur Ahmad |
Dentistry |
$25,000 |
| Cellular and Animal Models of Mitochondrial Genetic Diseases |
Michael Koob |
Medical School |
$25,000 |
| Fludarabine Systemic Exposure in Patients Undergoing Allogeneic |
Pamala Jacobson |
Pharmacy |
$25,000 |
| Francisella Tularensis Genes Induced During Intracellular Growth in Macrophages |
Sandra Armstrong |
Medical School |
$25,000 |
| Exploring the Role of AFAP-110 in Growth Cone Motility |
Lorene Lanier |
Medical School |
$25,000 |
| Development of Articular Cartilage Implants Using MAPC |
Timothy O'Brien |
Veterinary Medicine |
$25,000 |
| |
|
|
|
| Seed Grant Summary 2002 |
|
|
|
| Optical Highlighters as a Novel Imaging Probes for Cell Biology |
Jonathan Marchant |
Medical School |
$24,107 |
| Isolation of Factors Required for Interphase Chromatin Compartmentalization in Yeast |
Duncan Clark |
Medical School |
$25,000 |
| Antigen-specific model of inflammatory bowel disease |
Alexander Khoruts |
Medical School |
$25,000 |
| A Population-based Study of Rectal Complications after Radiation for Prostate Cancer |
Nancy Baxter |
Medical School |
$25,000 |
| Cartilage Matrix Structure/Function Using Genetically Engineered Chrondocytes |
Jack Lewis Jennifer Westendorf |
Medical School Medical School |
$25,000 |
| Statistical Assessment of "More Guns, Less Crime" |
Patricia Grambsch |
Public Health |
$24,892 |
| Supercomputer Modeling of Airborne Particle Filtration |
Peter Raynor |
Public Health |
$24,977 |
| Functional Genomics and Proteomics of Retinal Proteins |
Deborah Ferrington Timothy Olsen |
Medical School Medical School |
$25,000 |
| Replacement of Retinal Neurons by Transplantation |
Steve McLoon |
Medical School |
$24,972 |
| Effect of Smoking Reduction/Cessation on Biomarkers of Osteoporosis in Light and Heavy Smokers: A Pilot Study |
Sharon Allen |
Medical School |
$24,312 |
| Melaleuca alternifolia Essential Oil for Treatment of Wounds Infected with Staphylococcus aureus |
Linda Halcon Marc Swiontkowski Dean Tsukayama |
Nursing Medical School Medical School |
$24,965 |
| Stem Cells and Age-Related Hearing and Balance Losses |
John Anderson Steve Juhn William Jurney |
Medical School Medical School Medical School |
$25,000 |
| |
|
|
|
| See Grant Summary 2001 |
|
|
|
| Structure-Function Studies of Carcinogenic DNA-Nitrosamine Adducts |
Natalia Tretyakova , David Ferguson |
Medical School/Pharmacy |
$25,000 |
| Role of Eosinophil Peroxidase in Asthma |
Arne Slungaard |
Medical School |
$25,000 |
| Reconstituted Bruch's Membrane and Retinal Pigment Epithelium |
Shalesh Kaushal |
Med School |
$25,000 |
| Epidemiology of Autism Spectrum Disorder |
James Gurney |
Med School |
$25,000 |
| Identification of Molecular Differences in Asthma Phenotypes |
Jean Regal |
Med School (D) |
$25,057 |
| Enteric Nerve Biopsy to Diagnose Diabetic Autonomic Neuropathy |
William Kennedy |
Med School |
$24,947 |
| Influence of Physiology and Microenvironment on Cryotherapy |
Robert Griffin |
Med School |
$24,692 |
| Analysis by DNA Microarrays of Altered Gene Expression by Bovine Macrophages in Response to Infection with Mycobacterium Avium Subspecies Paratuberculosis |
Douglas Weiss |
Vet Med |
$24,983 |
| Multipotent Adult Progenitor Cells for Treatment of Corneal Surface Defects |
Allison Hubel |
Med School |
$24,576 |
| Expression Profiling of the Human Mucosal Immune Response to HIV Infection |
Michael Murtaugh |
Ved Med |
$24,954 |
| Pharmacokinetics of Prophylactic Mycophenolate Following Allogeneic Stem Cell Transplantation in Adult and Pediatric Patients |
Pamala Jacobson |
Pharm |
$25,000 |
| Development of a Novel Intranasal Diazepam Delivery System for Treatment of Seizure Emergencies |
James Cloyd / Ronald Siegel |
Pharm |
$25,000 |
| An in vivo Model of Multipotent Adult Progenitor Cell Implants for the Treatment of Articular Cartilage Defects of the Knee |
Robert LaPrade / Cathy Carlson |
Med School/ Vet Med |
$25,000 |
| Identification of Stroke-Susceptibility Genes in the Mouse |
Robert Cormier |
Med School (D) |
$25,000 |
| |
|
|
|
| Seed Grant Summary 2000 |
|
|
|
| Prevalence and Correlates of Skin Problems Associated with Incontinence in Nursing Home Elders |
Donna Bliss |
Nursing |
$25,000 |
| Intracellular Trafficking of Pathogenic Alphaviruses in Insect Cell Hosts |
Kathleen Conklin |
Medical School |
$25,000 |
| Access to Care for American Indian Children with Special Health Care Needs |
Ann Garwick |
Nursing |
$25,000 |
| Peripheral Nerve Growth Factor and Muscle Hyperalgesia |
Lois Kehl/ Alvin Beitz |
Dental School/ Veterinary Medicine |
$21,000 |
| Converting Bone Marrow Stem Cells into Cholinergic Neurons |
Walter Low/ Catherine Verfaille |
Medical School/ Medical School |
$24,905 |
| Risk of Porcine Picornavirus in Xenotransplantation |
Moses Njenga |
Veterinary Medicine |
$25,558 |
| High throughput Cloning and Expression in Gram Positive Pathoger |
Douglas Ohlendorf |
Medical School |
$25,000 |
| Pathogenicity of a Newly Identified European-Like Porcine Reproductive and Respiratory Isolate in Pregnant Sows |
Kurt Rossow/ Scott Dee |
Veterinary Medicine |
$25,033 |
| Development of a Mouse Cochlea Database |
Peter Santi |
Medical School |
$25,000 |
| A New Model of Ubiquitin Function in Protein Degradation |
Robert Sheaff |
Medical School |
$25,000 |
| Design and Evaluation of Novel Inducers of Gene Expression |
Carston Wagner/ Daniel Vallera |
Pharmacy/Medical School |
$25,087 |
| |
|
|
|
| Seed Grant Summary 1999 |
|
|
|
| Modulation of Mitogen-Activated Protein Kinase Pathways by Genotoxic Alkylating Agents |
Lisa Peterson/ Elizabeth Wattenberg |
Public Health/ Public Health |
$24,923 |
| Nitroxyl Donors: Prodrugs of Nitroxyl for the Treatment of Male Erectile Dysfunction |
Earl Dunham |
Medical School |
$25,000 |
| Signaling Regulation in Angiogenesis |
Yun Qiu |
Medical School |
$25,000 |
| Protein Metabolism in Neonates with Sepsis Syndrome |
Sarah Jane Schwarzenberg |
Medical School |
$25,000 |
| Engineered Specificity Directed Against the CD19 Antigen Using Chimeric Single Chain Fv Constructs |
Paul Orchard |
Medical School |
$24,813 |
| Identification of Chromosomal Segments Containing Disease Causing Genes in the Horse by Genomic Mismatch Scanning |
James Mickelson |
Veterinary Medicine |
$24,826 |
| Subtype Selective Nicotine Agonists for Treatment of Cognitive Dysfunction |
S. Mbau N. Efange |
Medical School |
$17,800 |
| Functional Anaylsis of Mammalian Lats2, a Newly Identified Tumor Suppressor, in Tumorigenesis, Development, and Cell Cycle Control |
Wufan Tao |
Medical School |
$25,000 |
| Coronary Artery Disease and Cytomegalovirus: Are They Linked? |
M. Kent Froberg |
Medical School |
$24,765 |
| Pathogenicity of a Newly Isolated Mycoplasma in Pregnant Sows |
Han Soo Joo |
Veterinary Medicine |
$24,027 |
| |
|
|
|
| Seed Grant Summary 1997-1998 |
|
|
|
| Transgenic Model of T-Cell Autoimmune Arthritis |
Daniel Mueller |
Medical School |
$24,079 |
| Biomechanical Fatigue Effects and Risk Factors in Coronary Plaque Rupture |
Antheunis Versluis/ Alan Bank |
Dental School/ Medical School |
$20,500 |
| A Model for Studying Human Osteoclast Formation at Sites of Breast Cancer Metastases to Bone |
Denis Clohisy/ Catherine Verfaillie |
Medical School/ Medical School |
$25,000 |
| Cigarette Cessation Among Youth |
Dorothy Hatsukami/ Sharon Allen |
Medical School/ Medical School |
$25,000 |
| Development of an Electromyograph (EMG) System to Diagnose Nocturnal Bruxism |
John Schulte |
Dental School/ Medical School |
$25,000 |
| Transgenic Bcl-xL Mice and the Generation of B Cell Tumors |
Brian Van Ness |
Medical School |
$25,000 |
| Novel Ribosomal Targets for Development of Antimicrobial Chemotherapeutic Agents |
Gary Dunny |
Medical School |
$24,866 |
| Establishment of a Clinical Trials Research Center for Swine |
Robert Morrison/ JinLiang Xue |
Veterinary Medicine/Veterinary Medicine |
$23,800 |
| Artificial Presentation of a Superantigen on Tumor Cells: A Novel Method to Elicit Anti-Tumor Immunity |
S. Ramakrishnan |
Pharmacy |
$25,000 |
| Development of an Animal Model System to Study the Dissemination of Ovarian Carcinoma |
Amy Skubitz |
Medical School |
$25,000 |
