| AHC Seed Grant Recipients |
| Title | Principal Investigator(s) | College | Request |
| Seed Grant Summary 2009 | | | |
| Diabetic phenotype of mice with knockdown of adenosine kinase in myeloid cells | Yuqing Huo, MD, Ph.D. | Medical School | $25,000 |
| The Role of interferon-regulated chemokines in human lupus | Emily C. Gillespie, Ph.D. | Medical School | $25,000 |
| Functional Evaluation of Neural Networks in a Dish: Effect of Apolipoprotein E | Apostolos Georgopoulos, MD, Ph.D. | Medical School | $25,000 |
| Role of BCOR in Eye Development | Vivian J. Bardwell, Ph.D. | Medical School | $25,000 |
| Novel non-integrating lentiviral vectors for tumor-specific killing | Nicola Philpott, PhD | Medical School | $25,000 |
| Endothelial Microparticles: A Novel Non-Invasive Biomarker of Antibody-Mediated Kidney Transplant Rejection | Behzad Najafian, MD | Medical School | $25,000 |
| Development of a simulation model to predict effective strategies for pertussis control in Minnesota | Shalini Kulasingam, PhD | Public Health | $22,339 |
| Anti-cancer mechanisms of factors associated with pregnancy and preeclampsia | Jeffrey S. Gilbert, PhD | Medical School - Duluth | $24,762 |
| Natural language processing of Omaha System text data: A use case of medical text-mining in community-based care documentation | Genevieve B. Melton-Meaux, MA, MD | Medical School | $24,243 |
| Tension-type headache and temporomandibular disorder pain: distinct entities or a regional craniofacial pain disorder? | Mike T. John, DDS, MPH, PhD | School of Dentistry | $24,948 |
| Validating Clinical Measures of Executive Function in US Veterans | Fang Yu, PhD | School of Nursing | $25,000 |
| iTRAQ proteomic profiling of protein methylation during neural crest migration | Laura S. Gammill, PhD | Medical School | $25,000 |
| Targeted siRNA Delivery by self-assembling antibodies | Carston R. Wagner, PhD | College of Pharmacy | $25,000 |
| Alternative Method for Cervical Cancer Screening: Self Sample Collection for Human Papillomavirus Testing | Rahel Ghebre, MD, FACOG | Medical School | $25,000 |
| Magnetic Resonance Imaging and Spectroscopy of the Ovaries at 3 Tesla | Levi S. Downs, Jr. MD | Medical School | $25,000 |
| Seed Grant Summary 2008 | | | |
| Structural studies of the NL63 coronavirus spike protein by cryo-electrom microscopy | Fang Li, Ph.d. | Medical School | $25,000 |
| Novel role for Rtf1 in dedifferentiation and acquisition of pluripotency | Nobuaki Kikyo, MD, Ph.D. | Medical School | $25,000 |
| A novel role of The Cohesin Ring in Centrosome Dynamics | Duncan J. Clarke, Ph.D. | Medical School | $25,000 |
| Identification of genes that regulate in the selective packaging and transport of C. elegans LRP-1 | Sean D. Conner, Ph.D. | Medical School | $25,000 |
| Role of Two-component Signal SaeRS Regulator in Biofilm Formation of Staphylococcus aureus | Yinduo Ji, Ph.D. | College of Veterinary Medicine | $25,000 |
| Translational Control of Regulatory T Cell Induction | Alexander Khoruts, M.D. | Medical School | $25,000 |
| Information-seeking and decision-making preferences among orthodontic patients: an elective health care model | James R. Miller, DDS, MS | School of Dentistry | $25,000 |
| Whole-body MRI Bone Marrow Staging of Canine Lymphoma: a potential animal model | Daniel A. Feeney, DVM, MS | College of Veterinary Medicine | $25,000 |
Reproduction and immune function in Pteropus bats: Improving bio-monitoring capacity in a major wildlife reservoir for emerging infectious disease | Katharine M. Pelican, DVM, Ph.D. | College of Veterinary Medicine | $25,000 |
| Integration of Neuroimaging and Biomechanics of Low Back Pain | David J. Nuckley, Ph.D. | Medical School | $25,000 |
| Effects of Opioids on the Developing Rat Brain | Raghavendra Rao, MD | Medical School | $25,000 |
| Neural Circuit Plasticity in Models of Depressive Illness | Mark Thomas, Ph.D. | Medical School | $25,000 |
| High Throughput Screening the IGF - IR/GIPC Interaction: A New Strategy for Chemotherapy | David M. Ferguson, Ph.D. | College of Pharmacy | $25,000 |
| Cellular Therapy for Epidermolysis Bullosa | Jakub Tolar, MD, Ph.D. | Medical School | $24,596 |
| Novel live safe vaccine strategy against cytomegalovirus in the mouse model | Alistair Mcgregor, Ph.D. | Medical School | $25,000 |
| Seed Grant Summary 2007 | | | |
| Stress-Induced Binge Eating: A Prelude of Obesity | | | | $25,000 |
| Mechanisms of Drug Addiction: the Role of a New Gene, R7BP | | | | $25,000 |
| Stimulation of alveolar fluid clearance by carbonic anhydrase inhibition | | | | $25,000 |
| Hypocretin Mechanisms in Nicotine Reinforcement | | | William A. Corrigall, PhD | | | $24,760 |
| Curing Prion Disease with Recombinant Prior Proteins | | | | College of Veterinary Medicine | | $25,000 |
| Screening, Design and Optimization of Novel Small-Molecule, Druglike Anthrax Toxin Lethal Factor (LF) Inhibitors | | | | $25,000 |
| ACE-MSCs as Therapeutic Cytoreagents | | | | $25,000 |
| Testing of an Active Noise Cancellation System for Infant Incubators | | | Janet Lyn Fitzakerley, PhD | | | $21,861 |
| Diabetic phenotype of adenosine receptor 2A deficient mice | | | | $25,000 |
| The Mechanism of Stromal Cell Induced Commitment of Hematopoietic Progenitor Cells to the NK Cell Lineage | | | | $25,000 |
| Application of aptamer coated magnetic nanosensors to pathogen detection in complex matrices | | | Srinand Sreevatsan, MVSc, MPH, PhD | | | College of Veterinary Medicine | | $25,000 |
| A Novel Mechanical-Optical Probe for evaluating Cartilage and Osteoarthritis | | | | $25,000 |
| Novel Γ-Lactone/Lactam-Β-Lactone Hybrid Molecules as Non-Peptidyl Proteasome Inhibitors | | | Venkatram R. Mereddy, PhD | | | $25,000 |
| Neovasculogensis after chronic hypoxia | | | | $21,020 |
| | | | |
| Seed Grant Summary 2006 | | | |
| The Role of delta-EF1 in Skeletal Patterning | Michel M. Sanders | Medical School | $25,000 |
| SCF Ubiquitin Ligases and DNA Replication | Deanna Koepp | Medical School | $25,000 |
| Identification and tracking of novel antibiotic resistance genes in bacteria isolated from wastewater treatment plants | Jeffrey A. Gralnick | Medical School | $25,000 |
| The Control of Adipose Biology by the Renin-Angiotensin System | Stephen A. Katz | Medical School | $24,982 |
| Development of an in vivo assay system to study gene function in the chick retina | Naoko Koyano-Nakagawa | Medical School | $25,000 |
| Gene Therapy for Parkinson's | John Ohlfest | Medical School | $24,933 |
| Role of a Chromatin-Modifying Enzyme in Prostate Cancer | Jeffrey A. Simon | Medical School | $25,000 |
| Energy Metabolism of Pancreatic Islets: Effects of Oxygenation Status and Antioxidants | Gulin Oz | Medical School | $25,000 |
| Biosphosphate Associated Osteonecrosis of the Jaws: Utilization of a Novel Dual Energy Micro-CT Protocol to Study Changes in Vascular Characteristics and Bone Changes | Rajaram Gopalakrishnan | School of Dentistry | $25,000 |
| Structural Basis of Sleeping Beauty - Mediation Transposition | Irina Nesmelova | Medical School | $25,000 |
| Gold Nanoparticles for Delivery of Transposons to the Liver | Stephen C. Ekker | Medical School | $25,000 |
| Latino Mental Health | Nancy C. Raymond | Medical School | $24,926 |
| A feasibility study of a novel Ca marker to asses bone turnover for breast cancer patients treated with aromatase inhibitor and bisphosphonate drug | Susanta Hui | Medical School | $24,888 |
| Biomechanics of Fetal Membrane Rupture | Phillip Rauk | Medical School | $25,000 |
| Self-gelling Antimicrobial System for Infection Prevention in Root Canal | Walter Bowles | School of Dentistry | $25,000 |
| | | | |
| Seed Grant Summary 2005 | | | |
| Comparison of X chromosome inactivation in multipotent adult progenitor cells and embryonic stem cells | Nobuaki Kikyo, M.D., Ph.D. | Medical School | $25,000 |
| Kinetic Determinants of Ubiguitin Signaling | Kylie Walters, Ph.D. | Medical School | $24,944 |
| Differentiation of Cochlear Progenitor Cells from Bone Marrow Stem Cells in Mice | Jizhen Lin, M.D. | Medical School | $25,000 |
| Biosynthesis of cytotoxic mushroom sesquiterpenes as anticancer drugs | Claudia Schmidt Dannert, Ph.D. | Medical School | $25,000 |
| Intranasal Application of Neuroprotective Agents in Rats with Anterior Ischemic Optic Neuropathy | Linda McLoon, Ph.D. | Medical School | $25,000 |
| A Randomized, Double-Blinded, Placebo-Controlled Study of Intra-articular Botulinum Toxin A for Painful Prosthetic Hip Joint | Jasvinder Singh, M.D., M.P.H. | Medical School | $25,000 |
| Effect of Altered Arginine Metabolism in Asthma | Mark Rutherford, Ph.D. | College of Veterinary Medicine | $25,000 |
| Chemical Synthesis and Biophysical Analysis of Peptides for HIV Therapeutics | Christine Karim, Ph.D. | Medical School | $25,000 |
| The role of CD4+CD3-accessory cells in regulation of T cell responses and autoimmunity | Alexander Khoruts, M.D. | Medical School | $25,000 |
| Antibiotics from Unculturable Microorganisms | Wayne Shier, Ph.D. | College of Pharmacy | $25,000 |
| Functional Genomics Analyses of Highly Pathogenic Avian Influenza | Vivek Kapur, BVSc, PhD | Medical School | $25,000 |
| Algorithms for Identification of Acute Stroke Cases in Medicare Data | Kamakshi Lakshminarayan, M.D., Ph.D. | Medical School | $22,770 |
| Identifying signaling pathway-specific kinase targets using a functional proteomics approach | Ameeta Kelekar, Ph.D. | Medical School | $24,997 |
| | | | |
| Seed Grant Summary 2004 | | | |
| Regulation of Diabetes by Suppressor T Cells | Michael A. Farrar | Medical School | $25,000 |
| NMDA Receptor Function and Circadian Time | Paulo Kofuji | Medical School | $25,000 |
| Treatment of Plasmodium falciparum Parasitemia in Rural HIV-Infected Tanzanian Adults Initiating Highly Active Antiretroviral Therapy | Alan Lifson | Medical School | $25,000 |
| Unexpected apoptotic effect of small peptide on human cancer | Tucker Lebien | Medical School | $25,000 |
| Gene Expression Profiling of Lesion Subtypes in a Transgenic Mouse Model of Breast Tumorigenesis | Teresa Rose-Hellekant | Medical School-Duluth | $25,000 |
| The Influence of electrical charge on filtration of an airborne biological agent | Peter Raynor | School of Public Health | $24,996 |
| Use of Geographical Information Systems for Research into Endemic and Emerging Diseases of Swine (PRRS) | Peter Davies | College of Veterinary Medicine | $25,000 |
| The Role of Endothelial Cell Tissue Factor during Vascular Remodeling | David Basi | School of Dentistry | $25,000 |
| Role of Endosomal Adapter Proteins in Localization of BACE1 (B-site APP-Cleaving Enzyme) | Patricia Scott | Medical School-Duluth | $24,543 |
| Reovirus subversion of the unfolded protein response | Leslie Schiff | Medical School | $25,000 |
| Magnetic resonance probes of Duchenne Muscular Dystrophy | David Thomas | Medical School | $25,000 |
| Evaluation of Activin Signaling Proteins in Head and Neck Cancer | Patrick Gaffney | Medical School | $25,000 |
| | | | |
| Seed Grant Summary 2003 | |
| The Role of MUC2 in Min Tumorigenesis | Robert Cormier | Duluth SOM | $25,000 |
| Sensitizing Neuroblastoma Cells to Immune-Based Therapies | Michael Verneris | Medical School | $25,000 |
| Role of Tsg in Patterning and Development of the Mandible | Rajaram Gopalakrishnan | Dentistry | $25,000 |
| Global Analysis of mRNA in Reovirus-Infected T Cells | Paul Bohjanen | Medical School | $25,000 |
| Identification of Human smORFs | Edward Perkins | Duluth SOM | $23,442 |
| Pharmacogenomic Identification of a Novel Gene Target, Sprouty 1 | Jennifer Hall | Medical School | $25,000 |
| 3D Co-Culture of Oseoblasts and Endothelial Cells | Mansur Ahmad | Dentistry | $25,000 |
| Cellular and Animal Models of Mitochondrial Genetic Diseases | Michael Koob | Medical School | $25,000 |
| Fludarabine Systemic Exposure in Patients Undergoing Allogeneic | Pamala Jacobson | Pharmacy | $25,000 |
| Francisella Tularensis Genes Induced During Intracellular Growth in Macrophages | Sandra Armstrong | Medical School | $25,000 |
| Exploring the Role of AFAP-110 in Growth Cone Motility | Lorene Lanier | Medical School | $25,000 |
| Development of Articular Cartilage Implants Using MAPC | Timothy O'Brien | Veterinary Medicine | $25,000 |
| | | | |
| Seed Grant Summary 2002 | | | |
| Optical Highlighters as a Novel Imaging Probes for Cell Biology | Jonathan Marchant | Medical School | $24,107 |
| Isolation of Factors Required for Interphase Chromatin Compartmentalization in Yeast | Duncan Clark | Medical School | $25,000 |
| Antigen-specific model of inflammatory bowel disease | Alexander Khoruts | Medical School | $25,000 |
| A Population-based Study of Rectal Complications after Radiation for Prostate Cancer | Nancy Baxter | Medical School | $25,000 |
| Cartilage Matrix Structure/Function Using Genetically Engineered Chrondocytes | Jack Lewis Jennifer Westendorf | Medical School Medical School | $25,000 |
| Statistical Assessment of "More Guns, Less Crime" | Patricia Grambsch | Public Health | $24,892 |
| Supercomputer Modeling of Airborne Particle Filtration | Peter Raynor | Public Health | $24,977 |
| Functional Genomics and Proteomics of Retinal Proteins | Deborah Ferrington Timothy Olsen | Medical School Medical School | $25,000 |
| Replacement of Retinal Neurons by Transplantation | Steve McLoon | Medical School | $24,972 |
| Effect of Smoking Reduction/Cessation on Biomarkers of Osteoporosis in Light and Heavy Smokers: A Pilot Study | Sharon Allen | Medical School | $24,312 |
| Melaleuca alternifolia Essential Oil for Treatment of Wounds Infected with Staphylococcus aureus | Linda Halcon Marc Swiontkowski Dean Tsukayama | Nursing Medical School Medical School | $24,965 |
| Stem Cells and Age-Related Hearing and Balance Losses | John Anderson Steve Juhn William Jurney | Medical School Medical School Medical School | $25,000 |
| | | | |
| See Grant Summary 2001 | | | |
| Structure-Function Studies of Carcinogenic DNA-Nitrosamine Adducts | Natalia Tretyakova , David Ferguson | Medical School/Pharmacy | $25,000 |
| Role of Eosinophil Peroxidase in Asthma | Arne Slungaard | Medical School | $25,000 |
| Reconstituted Bruch's Membrane and Retinal Pigment Epithelium | Shalesh Kaushal | Med School | $25,000 |
| Epidemiology of Autism Spectrum Disorder | James Gurney | Med School | $25,000 |
| Identification of Molecular Differences in Asthma Phenotypes | Jean Regal | Med School (D) | $25,057 |
| Enteric Nerve Biopsy to Diagnose Diabetic Autonomic Neuropathy | William Kennedy | Med School | $24,947 |
| Influence of Physiology and Microenvironment on Cryotherapy | Robert Griffin | Med School | $24,692 |
| Analysis by DNA Microarrays of Altered Gene Expression by Bovine Macrophages in Response to Infection with Mycobacterium Avium Subspecies Paratuberculosis | Douglas Weiss | Vet Med | $24,983 |
| Multipotent Adult Progenitor Cells for Treatment of Corneal Surface Defects | Allison Hubel | Med School | $24,576 |
| Expression Profiling of the Human Mucosal Immune Response to HIV Infection | Michael Murtaugh | Ved Med | $24,954 |
| Pharmacokinetics of Prophylactic Mycophenolate Following Allogeneic Stem Cell Transplantation in Adult and Pediatric Patients | Pamala Jacobson | Pharm | $25,000 |
| Development of a Novel Intranasal Diazepam Delivery System for Treatment of Seizure Emergencies | James Cloyd / Ronald Siegel | Pharm | $25,000 |
| An in vivo Model of Multipotent Adult Progenitor Cell Implants for the Treatment of Articular Cartilage Defects of the Knee | Robert LaPrade / Cathy Carlson | Med School/ Vet Med | $25,000 |
| Identification of Stroke-Susceptibility Genes in the Mouse | Robert Cormier | Med School (D) | $25,000 |
| | | | |
| Seed Grant Summary 2000 | | | |
| Prevalence and Correlates of Skin Problems Associated with Incontinence in Nursing Home Elders | Donna Bliss | Nursing | $25,000 |
| Intracellular Trafficking of Pathogenic Alphaviruses in Insect Cell Hosts | Kathleen Conklin | Medical School | $25,000 |
| Access to Care for American Indian Children with Special Health Care Needs | Ann Garwick | Nursing | $25,000 |
| Peripheral Nerve Growth Factor and Muscle Hyperalgesia | Lois Kehl/ Alvin Beitz | Dental School/ Veterinary Medicine | $21,000 |
| Converting Bone Marrow Stem Cells into Cholinergic Neurons | Walter Low/ Catherine Verfaille | Medical School/ Medical School | $24,905 |
| Risk of Porcine Picornavirus in Xenotransplantation | Moses Njenga | Veterinary Medicine | $25,558 |
| High throughput Cloning and Expression in Gram Positive Pathoger | Douglas Ohlendorf | Medical School | $25,000 |
| Pathogenicity of a Newly Identified European-Like Porcine Reproductive and Respiratory Isolate in Pregnant Sows | Kurt Rossow/ Scott Dee | Veterinary Medicine | $25,033 |
| Development of a Mouse Cochlea Database | Peter Santi | Medical School | $25,000 |
| A New Model of Ubiquitin Function in Protein Degradation | Robert Sheaff | Medical School | $25,000 |
| Design and Evaluation of Novel Inducers of Gene Expression | Carston Wagner/ Daniel Vallera | Pharmacy/Medical School | $25,087 |
| | | | |
| Seed Grant Summary 1999 | | | |
| Modulation of Mitogen-Activated Protein Kinase Pathways by Genotoxic Alkylating Agents | Lisa Peterson/ Elizabeth Wattenberg | Public Health/ Public Health | $24,923 |
| Nitroxyl Donors: Prodrugs of Nitroxyl for the Treatment of Male Erectile Dysfunction | Earl Dunham | Medical School | $25,000 |
| Signaling Regulation in Angiogenesis | Yun Qiu | Medical School | $25,000 |
| Protein Metabolism in Neonates with Sepsis Syndrome | Sarah Jane Schwarzenberg | Medical School | $25,000 |
| Engineered Specificity Directed Against the CD19 Antigen Using Chimeric Single Chain Fv Constructs | Paul Orchard | Medical School | $24,813 |
| Identification of Chromosomal Segments Containing Disease Causing Genes in the Horse by Genomic Mismatch Scanning | James Mickelson | Veterinary Medicine | $24,826 |
| Subtype Selective Nicotine Agonists for Treatment of Cognitive Dysfunction | S. Mbau N. Efange | Medical School | $17,800 |
| Functional Anaylsis of Mammalian Lats2, a Newly Identified Tumor Suppressor, in Tumorigenesis, Development, and Cell Cycle Control | Wufan Tao | Medical School | $25,000 |
| Coronary Artery Disease and Cytomegalovirus: Are They Linked? | M. Kent Froberg | Medical School | $24,765 |
| Pathogenicity of a Newly Isolated Mycoplasma in Pregnant Sows | Han Soo Joo | Veterinary Medicine | $24,027 |
| | | | |
| Seed Grant Summary 1997-1998 | | | |
| Transgenic Model of T-Cell Autoimmune Arthritis | Daniel Mueller | Medical School | $24,079 |
| Biomechanical Fatigue Effects and Risk Factors in Coronary Plaque Rupture | Antheunis Versluis/ Alan Bank | Dental School/ Medical School | $20,500 |
| A Model for Studying Human Osteoclast Formation at Sites of Breast Cancer Metastases to Bone | Denis Clohisy/ Catherine Verfaillie | Medical School/ Medical School | $25,000 |
| Cigarette Cessation Among Youth | Dorothy Hatsukami/ Sharon Allen | Medical School/ Medical School | $25,000 |
| Development of an Electromyograph (EMG) System to Diagnose Nocturnal Bruxism | John Schulte | Dental School/ Medical School | $25,000 |
| Transgenic Bcl-xL Mice and the Generation of B Cell Tumors | Brian Van Ness | Medical School | $25,000 |
| Novel Ribosomal Targets for Development of Antimicrobial Chemotherapeutic Agents | Gary Dunny | Medical School | $24,866 |
| Establishment of a Clinical Trials Research Center for Swine | Robert Morrison/ JinLiang Xue | Veterinary Medicine/Veterinary Medicine | $23,800 |
| Artificial Presentation of a Superantigen on Tumor Cells: A Novel Method to Elicit Anti-Tumor Immunity | S. Ramakrishnan | Pharmacy | $25,000 |
| Development of an Animal Model System to Study the Dissemination of Ovarian Carcinoma | Amy Skubitz | Medical School | $25,000 |
